Scientific report 2024 of the Chronic Malignancies Working Party (CMWP)

It is a pleasure to look back on the last 12 months!

We have really refined our study portfolio to enhance scientific output and prioritise contemporary studies. The CMWP has published extensively in this 12-month period, including 22 publications as detailed below, and also presented oral and poster abstracts at both EBMT24 and ASH24. I would particularly like to highlight the practice harmonisation papers led by the CMWP including Optimisation of allo-HCT in Advanced Mastocytosis. ‘Watch this space’ for our upcoming international guidelines on clinical-genomic profiling to guide allo-HCT in MDS and the role of allo-HCT in non-classical MPNs and MDS/MPN overlap syndromes! These much needed guidelines will be published imminently. 

The CMWP held really productive Business and Educational meetings in Glasgow (AGM) and more recently in Warsaw, November 2024, where we focused on optimizing outcomes in allogeneic HCT for MDS, MPN, and MDS/MPN overlap syndromes. The state-of-the art educational program covered advancements in transplant strategies, covering utilisation of molecular risk stratification in MDS and Myelofibrosis to guide the transplant decision, including how best  to address the challenges of managing TP53-mutant MDS, the use of novel agents peri-HCT, and the potential use of CAR-T in MF as developed by Dr. Alexandros Rampotas, University College London, to name a few of the many topics covered. The meeting emphasized a need for more international collaboration and trials focused on these disorders. Future CMWP educational meetings are planned for Rome in September 2025 alongside the ADWP and we hope to see you there for an exciting and innovative event!

Finally, let me express my thanks and admiration for the entire CMWP team, including all the principal investigators, subcommittees and the data management/programming team/ statisticians and members who have worked tirelessly on all of our studies. Their outstanding knowledge, support and collaborative nature has been amazing!